Which of the following international protocols specifically addresses the prevention, suppression and punishment of trafficking in persons, especially women and children?

The Palermo Protocol, formally known as the Protocol to Prevent, Suppress and Punish Trafficking in Persons, Especially Women and Children, was adopted by the United Nations in 2000 as a supplement to the UN Convention against Transnational Organized Crime. It provides the first internationally agreed definition of trafficking in persons and obligates signatory states to criminalise such acts. The other options address diplomatic relations, armed conflict, or regional economic integration, not human trafficking specifically.